Article
DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti-DKK1 therapeutic DKN-01.
Liver international : official journal of the International Association for the Study of the Liver - 1 Jan 2023
Jarman Edward J, Horcas-Lopez Marta, Waddell Scott H, MacMaster Stephanie, Gournopanos Konstantinos, Soong Daniel Y H, Musialik Kamila I, Tsokkou Panagiota, Ng Minn-E, Cambridge William A, Wilson David H, Kagey Michael H, Newman Walter, Pollard Jeffrey W, Boulter Luke
Abstract excerpt
BACKGROUND AND AIMS: Dickkopf-1 (DKK1) is associated with poor prognosis in intrahepatic cholangiocarcinoma (iCCA), but the mechanisms behind this are unclear. Here, we show that DKK1 plays an immune regulatory role in vivo and inhibition reduces tumour growth. METHODS: Various in vivo GEMM mouse models and patient samples were utilized to assess the effects of tumour specific DKK1 overexpression in iCCA....
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