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Serine/threonine kinase TBK1 promotes cholangiocarcinoma progression via direct regulation of β-catenin

16 Mar 2023

Abstract excerpt

Cholangiocarcinoma (CCA) is a highly heterogeneous and metastatic malignancy with a poor prognosis even after curative hepatectomy. Studies exploring its pathogenesis and identifying effective therapeutic targets are urgently needed. In this study, we found that TANK-binding kinase 1 (TBK1), a serine/threonine-protein kinase, showed a dynamic increase during the different stages of murine spontaneous CCA...

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PMID: 36928362
DOI: 10.1038/s41388-023-02651-4

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