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Article

Protective effect of vitamin E against chromosomal aberrations and mutation induced by sodium chromate in Chinese hamster V79 cells.

Mutation research - 1 May 1991

Sugiyama M, Lin X H, Costa M

Abstract excerpt

The effect of vitamin E on chromosomal aberrations and mutation caused by Na2CrO4 was investigated in Chinese hamster V79 cells. Pretreatment with 25 microM alpha-tocopherol succinate (vitamin E) for 24 h prior to chromate exposure (2.5-5 microM) resulted in a decrease of metal-induced chromosomal aberrations. Na2CrO4 (2.5-7.5 microM) induced mutations at the HGPRT locus, but only within a very limited...

Topics

Animals
Chromates
Chromosome Aberrations
Cricetinae
DNA
DNA Damage
Dose-Response Relationship, Drug
Drug Antagonism
In Vitro Techniques
Mutagenicity Tests
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sodium Compounds

Vitamin E

Source

Identifiers

PMID: 2027337
DOI: 10.1016/0165-1218(91)90076-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2027337-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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