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Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

5 Sept 2019

Abstract excerpt

INTRODUCTION: Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. Most such biomarker studies are targeted to specific proteins or are biased toward high abundant proteins. METHODS: 4001 plasma proteins were measured in two groups of participants (discovery group =...

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PMID: 31495601
DOI: 10.1016/j.jalz.2019.06.4951

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