Causal Association of Cardiovascular Risk Factors and Lifestyle Behaviors With Peripheral Artery Disease: A Mendelian Randomization Approach.

doi:10.1161/JAHA.122.025644

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Article

Causal Association of Cardiovascular Risk Factors and Lifestyle Behaviors With Peripheral Artery Disease: A Mendelian Randomization Approach.

Journal of the American Heart Association - 16 Aug 2022

Hoek Anna G, van Oort Sabine, Elders Petra J M, Beulens Joline W J

Abstract excerpt

Background We investigated the causal associations between the genetic liability to cardiovascular and lifestyle risk factors and peripheral artery disease (PAD), using a Mendelian randomization approach. Methods and Results We performed a 2-sample inverse-variance weighted Mendelian randomization analysis, multiple sensitivity analyses to assess pleiotropy and multivariate Mendelian randomization analyses to...

Topics

Cardiovascular Diseases
Cholesterol, HDL
Cholesterol, LDL
Coffee
Diabetes Mellitus, Type 2
Genome-Wide Association Study
Heart Disease Risk Factors
Humans
Life Style
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peripheral Arterial Disease

Polymorphism, Single Nucleotide

Risk Factors

Sleep Initiation and Maintenance Disorders

Smoking

Triglycerides

Source

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Identifiers

PMID: 35929454
DOI: 10.1161/JAHA.122.025644
PMCID: PMC9496309

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