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Article

The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.

The protein journal - 1 Apr 2018

Liu Xun, Zhang Yang, Hu Zhanhong, Li Qian, Yang Lu, Xu Guoqiang

Abstract excerpt

The ubiquitin proteasome system (UPS) plays important roles in the regulation of protein stability, localization, and activity. A myriad of studies have focused on the functions of ubiquitin ligases E3s and deubiquitinating enzymes DUBs due to their specificity in the recognition of downstream substrates. However, the roles of the most ubiquitin-conjugating enzymes E2s are not completely understood except that...

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Identifiers

PMID: 29564676
DOI: 10.1007/s10930-018-9766-x

Genes

CDC34

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