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Article

From polygenic risk to functional genomics: a framework for precision gynecological disease modeling.

Nature communications - 27 Aug 2026

Khatun Masuma, Tapanainen Juha S, Salumets Andres

Abstract excerpt

Gynecological conditions including endometriosis, polyendocrine metabolic ovarian syndrome and malignancies cause widespread chronic morbidity and infertility, yet translating genetic discoveries into biological mechanisms remains challenging. We propose a framework integrating biobank-derived human genetic data, patient-derived stem cell models, and advanced tissue engineering. By combining naturally occurring...

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Identifiers

PMID: 42660944
DOI: 10.1038/s41467-026-77342-1
PMCID: PMC13522561

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