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Article

Evidence that geographic variation in genetic ancestry associates with uterine fibroids.

Human genetics - 1 Oct 2021

Keaton Jacob M, Jasper Elizabeth A, Hellwege Jacklyn N, Jones Sarah H, Torstenson Eric S, Edwards Todd L, Velez Edwards Digna R

Abstract excerpt

Uterine fibroids disproportionately impact Black women. Evidence suggests Black women have earlier onset and higher cumulative risk. This risk disparity may be due an imbalance of risk alleles in one parental geographic ancestry subgroup relative to others. We investigated ancestry proportions for the 1000 Genomes phase 3 populations clustered into six geographic groups for association with fibroid traits in...

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Identifiers

PMID: 34302236
DOI: 10.1007/s00439-021-02322-y
PMCID: PMC8463481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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