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Genome wide association study of a Circadian Imbalance Index in 312,935 European ancestry UK Biobank participants identifies loci related to diabetes, mood and myocardial infarction

2025-12-12

Abstract excerpt

<title>Abstract</title> <p>The Circadian Imbalance Index (CII) integrates chronotype, sleep duration, neuroticism, caffeine intake, and vitamin D. In a genome wide association study (GWAS) of CII in 312,935 European ancestry UK Biobank participants, we identified 27 loci mapping to 72 genes, including circadian regulators CALCA, DHCR7, KDM5A, HAL, and CRX. Gene-overlap analyses demonstrated shared architecture wi...

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Literature Corpus work: 23fd8ae0-9abe-5c22-9068-0453e419fd1c
DOI: 10.21203/rs.3.rs-8329341/v1

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