Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role for alpha-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies.

Nature cell biology - 1 Aug 1999

Grady R M, Grange R W, Lau K S, Maimone M M, Nichol M C, Stull J T, Sanes J R

Abstract excerpt

A dystrophin-containing glycoprotein complex (DGC) links the basal lamina surrounding each muscle fibre to the fibre's cytoskeleton, providing both structural support and a scaffold for signalling molecules. Mutations in genes encoding several DGC components disrupt the complex and lead to muscular dystrophy. Here we show that mice deficient in alpha-dystrobrevin, a cytoplasmic protein of the DGC, exhibit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dystrophin
Share to Dystrophin-Associated Proteins
Share to Mice, Inbred mdx

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Models, Biological

Share to Muscle, Skeletal

Share to Muscular Dystrophy, Animal

Share to Neuropeptides

Source

Identifiers

PMID: 10559919
DOI: 10.1038/12034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role for alpha-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies.PMID 10559919Read ↗

Essential roles of the dystrophin-glycoprotein complex in different cardiac pathologiesSemantic proximity Read ↗

Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex.Semantic proximity Read ↗

Function and Genetics of Dystrophin and Dystrophin-Related Proteins in MuscleSemantic proximity Read ↗

The Dystrophin‐Glycoprotein Complex in the Prevention of Muscle DamageSemantic proximity Read ↗

The dystrophin–glycoprotein complex, cellular signaling, and the regulation of cell survival in the muscular dystrophiesSemantic proximity Read ↗

Chimaeric mice deficient in dystroglycans develop muscular dystrophy and have disrupted myoneural synapses.Semantic proximity Read ↗

Muscular dystrophies involving the dystrophin–glycoprotein complex: an overview of current mouse modelsSemantic proximity Read ↗

Consequences of disrupting the dystrophin-sarcoglycan complex in cardiac and skeletal myopathy.Semantic proximity Read ↗

zeta-Sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophySemantic proximity Read ↗

The root cause of Duchenne muscular dystrophy is the lack of dystrophin in smooth muscle of blood vessels rather than in skeletal muscle per seSemantic proximity Read ↗

From dystrophinopathy to sarcoglycanopathy: evolution of a concept of muscular dystrophy.Semantic proximity Read ↗

Functional characteristics of dystrophic skeletal muscle: insights from animal modelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.