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AR alterations inform circulating tumor DNA detection in metastatic castration resistant prostate cancer patients.

Nature communications - 11 Dec 2024

Knutson Todd P, Luo Bin, Kobilka Anna, Lyman Jacqueline, Guo Siyuan, Munro Sarah A, Li Yingming, Heer Rakesh, Gaughan Luke, Morris Michael J, Beltran Himisha, Ryan Charles J, Antonarakis Emmanuel S, Armstrong Andrew J, Halabi Susan, Dehm Scott M

Abstract excerpt

Circulating tumor DNA (ctDNA) in plasma cell free DNA (cfDNA) of cancer patients is associated with poor prognosis, but is challenging to detect from low plasma volumes. In metastatic castration-resistant prostate cancer (mCRPC), ctDNA assays are needed to prognosticate outcomes of patients treated with androgen receptor (AR) inhibitors. We develop a custom targeted cfDNA sequencing assay, named AR-ctDETECT, to...

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Androstenes
Aneuploidy
Benzamides
Circulating Tumor DNA
Neoplasm Metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prostatic Neoplasms, Castration-Resistant

Receptors, Androgen

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Open in PubMed Open full text

Identifiers

PMID: 39663356
DOI: 10.1038/s41467-024-54847-1
PMCID: PMC11634963

Genes

AR
MYC
MYCN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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