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Article

Control of Cellular Differentiation Trajectories for Cancer Reversion

11 Dec 2024

Abstract excerpt

Cellular differentiation is controlled by intricate layers of gene regulation, involving the modulation of gene expression by various transcriptional regulators. Due to the complexity of gene regulation, identifying master regulators across the differentiation trajectory has been a longstanding challenge. To tackle this problem, a computational framework, single-cell Boolean network inference and control...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39661721
DOI: 10.1002/advs.202402132

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