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Complexity of synovial fluid-derived monocyte-macrophage-lineage cells in knee osteoarthritis

1 Dec 2024

Abstract excerpt

Synovial fluid (SF)-derived monocyte-macrophage (MON-Mϕ)-lineage cells in knee osteoarthritis (KOA) remain poorly understood. We analyzed SF samples from 420 patients with KOA with effusion. The MON-Mϕ cells accounted for 47.4% (median; range 7.1%–94.4%) of CD45 + cells and consisted of four subpopulations that correlated with the distribution and activation of other immune cells. The most abundant subpopulation...

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PMID: 39661512
DOI: 10.1016/j.celrep.2024.115011

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