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Article

Genetic and epigenetic factors shape phenotypes and outcomes in systemic lupus erythematosus - focus on juvenile-onset systemic lupus erythematosus.

Current opinion in rheumatology - 1 Mar 2025

Charras Amandine, Hiraki Linda T, Lewandowski Laura, Hedrich Christian M

Abstract excerpt

PURPOSE OF REVIEW: Systemic lupus erythematosus (SLE) is a severe autoimmune/inflammatory disease. Patients with juvenile disease-onset and those of non-European ancestry are most severely affected. While the exact pathophysiology remains unknown, common and rare gene variants in the context of environmental exposure and epigenetic alterations are involved. This manuscript summarizes the current understanding of...

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PMID: 39660463
DOI: 10.1097/BOR.0000000000001072
PMCID: PMC11789615

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