Article
Comorbidities in early-onset sporadic versus presenilin-1 mutation-associated Alzheimer disease dementia: Evidence for dependency on Alzheimer disease neuropathological changes.
Journal of neuropathology and experimental neurology - 1 Feb 2025
Sepulveda-Falla Diego, Villegas Lanau Carlos Andrés, White Iii Charles, Serrano Geidy E, Acosta-Uribe Juliana, Mejía-Cupajita Barbara, Villalba-Moreno Nelson David, Lu Pinzhang, Glatzel Markus, Kofler Julia K, Ghetti Bernardino, Frosch Matthew P, Restrepo Francisco Lopera, Kosik Kenneth S, Beach Thomas G
Abstract excerpt
Studying comorbidities in early onset Alzheimer disease (AD) may provide an advantageous perspective on their pathogenesis because aging factors may be largely inoperative for these subjects. We compared AD comorbidities between early-onset sporadic cases and American and Colombian cases with PSEN1 mutations. AD neuropathological changes (ADNC) were very severe in all groups but more severe in the PSEN1 groups....
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