Article
Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies.
Acta neuropathologica - 1 May 2011
Nelson Peter T, Head Elizabeth, Schmitt Frederick A, Davis Paulina R, Neltner Janna H, Jicha Gregory A, Abner Erin L, Smith Charles D, Van Eldik Linda J, Kryscio Richard J, Scheff Stephen W
Abstract excerpt
Human studies are reviewed concerning whether "aging"-related mechanisms contribute to Alzheimer's disease (AD) pathogenesis. AD is defined by specific neuropathology: neuritic amyloid plaques and neocortical neurofibrillary tangles. AD pathology is driven by genetic factors related not to aging per se, but instead to the amyloid precursor protein (APP). In contrast to genes involved in APP-related mechanisms,...
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