Article
Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study.
JAMA neurology - 1 Sept 2016
Day Gregory S, Musiek Erik S, Roe Catherine M, Norton Joanne, Goate Alison M, Cruchaga Carlos, Cairns Nigel J, Morris John C
Abstract excerpt
IMPORTANCE: The amyloid hypothesis posits that disrupted β-amyloid homeostasis initiates the pathological process resulting in Alzheimer disease (AD). Autosomal dominant AD (ADAD) has an early symptomatic onset and is caused by single-gene mutations that result in overproduction of β-amyloid 42. To the extent that sporadic late-onset AD (LOAD) also results from dysregulated β-amyloid 42, the clinical phenotypes...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Case-Control Studies
- Disease Progression
- Family Health
- Female
- Humans
- Longitudinal Studies
- Male