Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting kinases with precision

28 Mar 2018

Abstract excerpt

Cancer genomics and mechanistic studies have revealed that heterogeneous mutations within a single kinase can result in a variety of activation mechanisms. The challenge has been to match these insights with tailored drug discovery strategies to yield potent, highly selective drugs. With optimized drugs in hand, physicians could apply the principles of personalized medicine with an increasing number of options to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Breast Cancer Therapies
Share to Cancer Genomics and Diagnostics
Share to Lung Cancer Treatments and Mutations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30250891
DOI: 10.1080/23723556.2018.1435183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting kinases with precisionPMID 30250891Read ↗

Kinase-targeted cancer therapies: progress, challenges and future directionsSemantic proximity Read ↗

Kinase inhibitors for precision therapy of triple-negative breast cancer: Progress, challenges, and new perspectives on targeting this heterogeneous diseaseSemantic proximity Read ↗

Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncologySemantic proximity Read ↗

A precision therapy against cancers driven by KIT/PDGFRA mutations.Semantic proximity Read ↗

The molecular basis of targeting protein kinases in cancer therapeutics.Semantic proximity Read ↗

Functional precision oncology: Testing tumors with drugs to identify vulnerabilities and novel combinations.Semantic proximity Read ↗

Personalized cancer therapy with selective kinase inhibitors: an emerging paradigm in medical oncology.Semantic proximity Read ↗

Selectivity filters to edit out deleterious side effects in kinase inhibitors.Semantic proximity Read ↗

Kinase Inhibitor Profiling Reveals Unexpected Opportunities to Inhibit Disease-Associated Mutant Kinases.Semantic proximity Read ↗

Rational therapeutic intervention in cancer: kinases as drug targets.Semantic proximity Read ↗

Polypharmacology is an enduring and nearly universal property of kinase inhibitorsSemantic proximity Read ↗

Targeting the Human Kinome for Cancer Therapy: Current PerspectivesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.