Homologous recombination-deficient high-grade serous ovarian cancers exhibit distinct morphological features.

doi:10.1016/j.ijgc.2026.104690

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Homologous recombination-deficient high-grade serous ovarian cancers exhibit distinct morphological features.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Sept 2026

Hanna Kattreen, Levin Gabriel, Al Nasir Miryam, Lacouline-Boulanger Roxanne, Shahbazian Lawrie, Diwan Sarah-Slim, Li Joyce, Hamidi Denia, Stephan Léa, Hmimas Mina, Zhang Nicole, Nathalie Nguyen Phuong-Nam, Richer Lara, Jacob Karine, Gomez Andrea, Ribeiro Reitan, Mandilaras Victoria, Bernard Laurence, Zeng Xing, Soslow Robert A, Gilbert Lucy, Annie Leung Shuk On, Tessier-Cloutier Basile

Abstract excerpt

OBJECTIVE: Access to homologous recombination testing remains limited in many centers. We aim to correlate the morphology and immunophenotype of high-grade serous ovarian carcinoma with homologous recombination statuses. METHODS: A retrospective analysis of a high-grade serous ovarian carcinoma tumors with known homologous recombination status. A pathological review of morphology was performed for each tumor,...

Read the complete abstract on PubMed

Topics

Humans
Female
Ovarian Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cystadenocarcinoma, Serous

Retrospective Studies

Middle Aged

Aged

Homologous Recombination

Neoplasm Grading

BRCA2 Protein

Genomic Instability

BRCA1 Protein

Mutation

Source

Open in PubMed

Identifiers

PMID: 42091345
DOI: 10.1016/j.ijgc.2026.104690

Genes

BRCA1
BRCA2
PAX8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homologous recombination-deficient high-grade serous ovarian cancers exhibit distinct morphological features.PMID 42091345Read ↗

Overview of Tumor Heterogeneity in High-Grade Serous Ovarian Cancers.Semantic proximity Read ↗

Can Morphology and Immune Infiltration Predict the Homologous Recombination Deficiency Status in Newly Diagnosed High-Grade Serous Ovarian Carcinoma?: Lessons From the PAOLA-1/ENGOT-ov25 Trial, a GINECO Study.Semantic proximity Read ↗

Homologous Recombination Proficiency in High-Grade Serous Epithelial Ovarian Cancer Tumors: The Dark Side of the MoonSemantic proximity Read ↗

Morphologic correlates of molecular alterations in extrauterine Müllerian carcinomas.Semantic proximity Read ↗

Toward More Comprehensive Homologous Recombination Deficiency Assays in Ovarian Cancer, Part 1: Technical ConsiderationsSemantic proximity Read ↗

Morphological and molecular characterization of epithelial ovarian cancer: SEOM-SEAP consensus guidelines for biomarker integration in clinical practice.Semantic proximity Read ↗

Concurrent RB1 loss and<i>BRCA</i>-deficiency predicts enhanced immunological response and long-term survival in tubo-ovarian high-grade serous carcinomaSemantic proximity Read ↗

Homologous recombination deficiency in high-grade serous ovarian carcinoma: clinical pathological characteristics, impact of neoadjuvant chemotherapy, and prognostic implications.Semantic proximity Read ↗

Ovarian high-grade serous carcinoma with transitional-like (SET) morphology: a homologous recombination-deficient tumor.Semantic proximity Read ↗

The Molecular Landscape of Ovarian Neoplasms: A Review.Semantic proximity Read ↗

The genesis and evolution of high-grade serous ovarian cancer.Semantic proximity Read ↗

Ovarian carcinomas: at least five different diseases with distinct histological features and molecular genetics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.