Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CXCR1+ neutrophil infiltration orchestrates response to third-generation EGFR-TKI in EGFR mutant non-small-cell lung cancer.

Signal transduction and targeted therapy - 6 Dec 2024

Wang Haowei, Xiong Anwen, Chen Xiaoxia, Guo Junhong, Tang Zhuoran, Wu Chunyan, Ren Shengxiang, Zhou Caicun, Chen Jian, Hou Likun, Jiang Tao

Abstract excerpt

Although third-generation Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) is standard of care for patients with EGFR-mutant Non-small cell lung cancer (NSCLC), little is known about the predictors of response or resistance. Here, we integrated single-cell RNA (scRNA) sequencing, bulk RNA sequencing, multiplexed immunofluorescence and flow cytometry data from pretreatment and post-resistant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Non-Small-Cell Lung
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to Lung Neoplasms

Share to Neutrophil Infiltration

Share to Neutrophils

Share to Protein Kinase Inhibitors

Share to Receptors, Interleukin-8A

Source

Open in PubMed Open full text

Identifiers

PMID: 39638994
DOI: 10.1038/s41392-024-02045-2
PMCID: PMC11621634

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CXCR1+ neutrophil infiltration orchestrates response to third-generation EGFR-TKI in EGFR mutant non-small-cell lung cancer.PMID 39638994Read ↗

Integrating Single-Cell RNA-seq to construct a Neutrophil prognostic model for predicting immune responses in non-small cell lung cancerSemantic proximity Read ↗

Integrating Single-cell RNA-seq to construct a Neutrophil prognostic model for predicting immune responses in non-small cell lung cancerSemantic proximity Read ↗

Cancer-associated Fibroblasts in Pan-Cancer Drive CXCR2+VNN2+ Neutrophils Reprogramming to Mediate Immunosuppression and Immunotherapy ResistanceSemantic proximity Read ↗

Neutrophils recruited by NKX2-1 suppression via activation of CXCLs/CXCR2 axis promote lung adenocarcinoma progressionSemantic proximity Read ↗

Single-cell RNA sequencing for the identification of early-stage lung cancer biomarkers from circulating bloodSemantic proximity Read ↗

High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancerSemantic proximity Read ↗

Prognostic value of the neutrophil-to-lymphocyte ratio and primary tumor location in patients with EGFR-mutated metastatic non-small cell lung cancer treated with TKIsNote: We found that we got a wrong results in the previous article. So, we checked our collected database and calculated again and corrected now.Semantic proximity Read ↗

Single-cell and spatial transcriptomics reveal that the CXCL12-CXCR4 axis drives the immune-desert phenotype in small cell lung cancer by recruiting immunosuppressive CXCR4+ neutrophils and S100A8+ monocytes.Semantic proximity Read ↗

Single-cell multi-omics analysis reveals heterogeneity and plasticity of neutrophil states in response to immunotherapiesSemantic proximity Read ↗

Characterising neutrophil subtypes in cancer using human and murine single-cell RNA sequencing datasetsSemantic proximity Read ↗

Tumor-associated neutrophils: orchestrating cancer pathobiology and therapeutic resistanceSemantic proximity Read ↗

Tumor‑associated neutrophils: Critical regulators in cancer progression and therapeutic resistance (Review)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.