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Article

Three-step surface design of spore-displayed keratinase improved acid tolerance and feather degradation.

International journal of biological macromolecules - 1 Jan 2025

Yan Mingchen, Chen Ying, Zhou Huimin, Feng Yong, Xu Yudan, Wang Zhen, Saeed Muhammad, Fang Zhen, Ni Zhong, Chen Huayou

Abstract excerpt

The global chicken business has grown rapidly, producing millions of tons of feather waste annually. Keratinase is a special enzyme that catalyzes the degradation of keratin and can be applied to the feed industry. In this study, we initially set the tone for the acid-resistant mutation of spore surface-display keratinase cotG-KERQ7 by replacing base-catalytic residues in the active center. We then performed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 39637749
DOI: 10.1016/j.ijbiomac.2024.138173

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