Article
Multi-pronged design enhances thermostability of zearalenone hydrolase ZenR for enzymatic detoxification of maize flour.
Bioresource technology - 1 Apr 2026
Hu Junqiang, Wu Yuzhuo, Zhang Mingliang, Han Tingting, Zhou Qiuyu, Liu Jinyue, Shan Yunfan, Wang Gang, Liu Xin, Shi Jianrong, Mohamed Sherif Ramzy, Lee Yin-Won, Xu Jianhong, Hong Qing
Abstract excerpt
Zearalenone (ZEN), an estrogenic mycotoxin commonly found in grains and feed, poses a severe threat to livestock production. The ZEN hydrolase ZenR, derived from Rhodococcus erythropolis HQ, exhibits high specific activity; however, its industrial application is constrained by limited thermostability. Through integrated computational design, consensus analysis, and molecular dynamics (MD) simulations, mutation...
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