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Modeling Trophoblast Cell-Guided Uterine Spiral Artery Transformation in the Rat

9 Mar 2022

Abstract excerpt

The rat possesses hemochorial placentation with deep intrauterine trophoblast cell invasion and trophoblast-guided uterine spiral artery remodeling, which resembles human placentation. Uterine spiral arteries are extensively remodeled to deliver sufficient supply of maternal blood and nutrients to the developing fetus. Inadequacies in these key processes negatively impact fetal growth and development. Recent...

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PMID: 35328368
DOI: 10.3390/ijms23062947

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