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Article

Genetically predicted metabolites mediate the causal associations between autoimmune thyroiditis and immune cells.

Frontiers in endocrinology - 1 Jan 2024

Chen Yongzhao, Jiang Bo, Qu Cheng, Jiang Chaoyu, Zhang Chen, Wang Yanxue, Chen Fei, Sun Xitai, Su Lei, Luo Yuqian

Abstract excerpt

Introduction: We aimed to comprehensively investigate the causal relationship between 731 immune cell traits and autoimmune thyroiditis (AIT) and to identify and quantify the role of 1400 metabolic traits as potential mediators in between. Methods: Using summary-level data from genome-wide association studies (GWAS) we performed a two-sample bidirectional Mendelian randomization (MR) analysis of genetically...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 39045270
DOI: 10.3389/fendo.2024.1424957
PMCID: PMC11263034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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