Influence of Nucleophosmin (NPM1) Genotypes on Outcome of Patients With AML: An AIEOP-BFM and COG-SWOG Intergroup Collaboration.

doi:10.1200/JCO-24-01715

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Article

Influence of Nucleophosmin (NPM1) Genotypes on Outcome of Patients With AML: An AIEOP-BFM and COG-SWOG Intergroup Collaboration.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Mar 2025

Tregnago Claudia, Benetton Maddalena, Ries Rhonda E, Peplinski Jack H, Alonzo Todd A, Stirewalt Derek, Othus Megan, Duployez Nicolas, Sonneveld Edwin, Abrahamsson Jonas, Fogelstrand Linda, von Neuhoff Nils, Hasle Henrik, Reinhardt Dirk, Meshinchi Soheil, Locatelli Franco, Pigazzi Martina

Abstract excerpt

PURPOSE: Several genomic subsets of NPM1 mutations with varying sequences (type A, B, D, etc) have been identified. Despite molecular heterogeneity, NPM1 mutations cumulatively portend a more favorable outcome, but biology and prognostic implications of different genomic subsets have not been extensively studied. In this multicentric study, we investigated the impact of NPM1 genotypes on patient's outcomes and...

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PMID: 39621969
DOI: 10.1200/JCO-24-01715
PMCID: PMC12363388

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NPM1

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