Article
Ddx46 is required for multi-lineage differentiation of hematopoietic stem cells in zebrafish.
Stem cells and development - 15 Sept 2013
Hirabayashi Ryo, Hozumi Shunya, Higashijima Shin-Ichi, Kikuchi Yutaka
Abstract excerpt
Balanced and precisely controlled processes between self-renewal and differentiation of hematopoietic stem cells (HSCs) into all blood lineages are critical for vertebrate definitive hematopoiesis. However, the molecular mechanisms underlying the maintenance and differentiation of HSCs have not been fully elucidated. Here, we show that zebrafish Ddx46, encoding a DEAD-box RNA helicase, is expressed in HSCs of the...
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