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Article

Mutation of Tubgcp6 induces hematopoietic stem and progenitor cell exhaustion in zebrafish.

Communications biology - 6 May 2026

Zhang Yuxian, Li Li, Chen Kemin, Chen Xiaohui, Liu Wei, Zhang Wenqing, Huang Zhibin

Abstract excerpt

Hematopoietic stem and progenitor cells (HSPCs) sustain blood cell production by balancing self-renewal and differentiation. While regulatory networks of transcription factors are well established during development of these cells, intrinsic cytoskeletal elements remain unclear. Here we show that the gamma-tubulin ring complex (γ-TuRC), a key regulator of microtubule nucleation, is essential for HSPC expansion in...

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Identifiers

PMID: 42092188
DOI: 10.1038/s42003-026-10209-9
PMCID: PMC13358126

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