Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic age acceleration predicts subject‐specific white matter degeneration in the human brain

28 Nov 2024

Abstract excerpt

Epigenetic clocks provide powerful tools for estimating health and lifespan but their ability to predict brain degeneration and neuronal damage during the aging process is unknown. In this study, we use GrimAge, an epigenetic clock correlated to several blood plasma proteins, to longitudinally investigate brain cellular microstructure in axonal white matter from a cohort of healthy aging individuals. A specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Neuroimaging Techniques and Applications
Share to Dementia and Cognitive Impairment Research
Share to MRI in cancer diagnosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39605173
DOI: 10.1111/acel.14426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic age acceleration predicts subject‐specific white matter degeneration in the human brainPMID 39605173Read ↗

Epigenetic Age Acceleration Assessed with Human White-Matter ImagesSemantic proximity Read ↗

A blood biomarker of accelerated aging in the body associates with worse structural integrity in the brain: replication across three cohortsSemantic proximity Read ↗

DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophySemantic proximity Read ↗

DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophySemantic proximity Read ↗

The Genetic Architecture of Multimodal Human Brain AgeSemantic proximity Read ↗

Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities studySemantic proximity Read ↗

Deep neural networks and genome-wide associations reveal the polygenic architecture of local brain aging.Semantic proximity Read ↗

Nongenetic and Genetic Factors Associated with White Matter Brain Aging: Exposome-Wide and Genome-Wide Association Study.Semantic proximity Read ↗

Distinct longitudinal brain white matter microstructure changes and associated polygenic risk of common psychiatric disorders and Alzheimer’s disease in the UK BiobankSemantic proximity Read ↗

The cellular associates of late life changes in white matter microstructureSemantic proximity Read ↗

The Vital Role of Central Executive Network in Brain Age: Evidence From Machine Learning and Transcriptional SignaturesSemantic proximity Read ↗

A spatially resolved genomic–molecular atlas of human white‑matter microstructureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.