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Accelerated aging of intervertebral discs in a mouse model of progeria

2 Jun 2010

Abstract excerpt

Intervertebral disc degeneration (IDD) is a common and debilitating disorder that results in reduced flexibility of the spine, pain, and reduced mobility. Risk factors for IDD include age, genetic predisposition, injury, and other environmental factors such as smoking. Loss of proteoglycans (PGs) contributes to IDD with advancing age. Currently there is a lack of a model for rapid investigation of disc aging and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20973062
DOI: 10.1002/jor.21153

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