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Article

Sarcopenia and Its Associated Metabolic Profile Predict Incident Heart Failure: A Prospective Cohort Study of 267 335 Adults in the UK Biobank.

Journal of the American Heart Association - 21 Jul 2026

Zhong Ziyi, Chen Yang, Xiang Qiao, Liu Hongyu, Zhao Manlin, Pekovic-Vaughan Vanja, Sund Reijo, Sankaranarayanan Rajiv, Cuthbertson Daniel J, Isanejad Masoud

Abstract excerpt

BACKGROUND: Sarcopenia is prevalent in heart failure (HF), but its role in incident HF and underlying metabolic mechanisms remains unclear. We examined the interplay between sarcopenia phenotypes, circulating metabolic profiles, and incident HF. METHODS: We analyzed UK Biobank participants without baseline HF. Associations between sarcopenia phenotypes and HF incidence were assessed using Cox regression. Nuclear...

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PMID: 42466482
DOI: 10.1161/JAHA.125.047621
PMCID: PMC13477333

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