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Article

Are the Common Genetic 3'UTR Variants in ADME Genes Playing a Role in Tolerance of Breast Cancer Chemotherapy?

International journal of molecular sciences - 15 Nov 2024

Tęcza Karolina, Kalinowska-Herok Magdalena, Rusinek Dagmara, Zajkowicz Artur, Pfeifer Aleksandra, Oczko-Wojciechowska Małgorzata, Pamuła-Piłat Jolanta

Abstract excerpt

We studied the associations between 3'UTR genetic variants in ADME genes, clinical factors, and the risk of breast cancer chemotherapy toxicity. Those variants and factors were tested in relation to seven symptoms belonging to myelotoxicity (anemia, leukopenia, neutropenia), gastrointestinal side effects (vomiting, nausea), nephrotoxicity, and hepatotoxicity, occurring in overall, early, or recurrent settings....

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PMID: 39596349
DOI: 10.3390/ijms252212283
PMCID: PMC11594993

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