Identification of ADME genes polymorphic variants linked to trastuzumab-induced cardiotoxicity in breast cancer patients: Case series of mono-institutional experience.

doi:10.1016/j.biopha.2024.116478

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Identification of ADME genes polymorphic variants linked to trastuzumab-induced cardiotoxicity in breast cancer patients: Case series of mono-institutional experience.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 May 2024

Staropoli Nicoletta, Scionti Francesca, Farenza Valentina, Falcone Federica, Luciano Francesco, Renne Maria, Di Martino Maria Teresa, Ciliberto Domenico, Tedesco Ludovica, Crispino Antonella, Labanca Caterina, Cucè Maria, Esposito Stefania, Agapito Giuseppe, Cannataro Mario, Tassone Pierfrancesco, Tagliaferri Pierosandro, Arbitrio Mariamena

Abstract excerpt

BACKGROUND: Long-term survival induced by anticancer treatments discloses emerging frailty among breast cancer (BC) survivors. Trastuzumab-induced cardiotoxicity (TIC) is reported in at least 5% of HER2+BC patients. However, TIC mechanism remains unclear and predictive genetic biomarkers are still lacking. Interaction between systemic inflammation, cytokine release and ADME genes in cancer patients might...

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PMID: 38547766
DOI: 10.1016/j.biopha.2024.116478

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