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Exploring genetic links between blood metabolites and gout susceptibility.

Clinical rheumatology - 1 Dec 2024

Zeng Wenxing, Hu Minhua, Zhou Lin, Cun Dejun, Ma Luyao, Zhang Jingtao, Huang Feng, Jiang Ziwei

Abstract excerpt

BACKGROUND: Gout, a prevalent form of inflammatory arthritis, has a complex etiology where the causal relationship between metabolites and the disease remains underexplored. This study aims to elucidate the impact of genetically determined blood metabolites on gout. METHODS: Employing a two-sample bidirectional Mendelian randomization analysis, we examined the association between 1400 blood metabolites and gout....

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PMID: 39467906
DOI: 10.1007/s10067-024-07215-9

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