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Article

DLK1 Is Associated with Stemness Phenotype in Medullary Thyroid Carcinoma Cell Lines.

International journal of molecular sciences - 6 Nov 2024

da Silva Danilo Dias, Araldi Rodrigo Pinheiro, Belizario Mariana Rocha, Rocha Welbert Gomes, Maciel Rui Monteiro de Barros, Cerutti Janete Maria

Abstract excerpt

Medullary thyroid carcinoma (MTC) is a rare and aggressive tumor, often requiring systemic treatment in advanced or metastatic stages, where drug resistance presents a significant challenge. Given the role of cancer stem cells (CSCs) in cancer recurrence and drug resistance, we aimed to identify CSC subpopulations within two MTC cell lines harboring pathogenic variants in the two most common MEN2-associated...

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Identifiers

PMID: 39595993
DOI: 10.3390/ijms252211924
PMCID: PMC11594232

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