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Article

Medullary thyroid carcinoma cell lines contain a self-renewing CD133+ population that is dependent on ret proto-oncogene activity.

The Journal of clinical endocrinology and metabolism - 1 Jan 2010

Zhu Wen, Hai Tao, Ye Lei, Cote Gilbert J

Abstract excerpt

CONTEXT: Medullary thyroid carcinoma (MTC) is a cancer of the parafollicular C cells commonly caused by an inherited or acquired RET proto-oncogene mutation. Therapeutic resistance and recurrence of the disease imply the presence of cancer stem cells in MTC. OBJECTIVE: In this study, we sought to identify and characterize cancer stem cell-like cells in MTC. MAIN OUTCOME MEASURES: The characterization of stem cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19897677
DOI: 10.1210/jc.2009-1485
PMCID: PMC2805480

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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