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Article

Association of Genomic Alterations with the Presence of Serum Monoclonal Proteins in Chronic Lymphocytic Leukemia.

Cells - 7 Nov 2024

Piñeyroa Juan A, López-Oreja Irene, Nadeu Ferran, Martínez-Farran Ares, Aróstegui Juan Ignacio, López-Guerra Mónica, Correa Juan Gonzalo, Fabregat Aleix, Villamor Neus, Monge-Escatín Ines, Albiol Nil, Costa Dolors, Aymerich Marta, Beà Sílvia, Campo Elías, Delgado Julio, Colomer Dolors, Mozas Pablo

Abstract excerpt

The presence of a monoclonal protein detected by serum immunofixation electrophoresis (sIFE) has been reported as an adverse prognostic factor in chronic lymphocytic leukemia (CLL). However, the genetic underpinning of this finding has not been studied. We retrospectively studied 97 CLL patients with simultaneous information on sIFE and genetic alterations detected by next-generation sequencing. sIFE was positive...

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Identifiers

PMID: 39594588
DOI: 10.3390/cells13221839
PMCID: PMC11592641

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