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Accelerating Heritability, Genetic Correlation, and Genome-Wide Association Imaging Genetic Analyses in Complex Pedigrees.

Human brain mapping - 1 Dec 2024

Donohue Brian, Gao Si, Nichols Thomas E, Adhikari Bhim M, Ma Yizhou, Jahanshad Neda, Thompson Paul M, McMahon Francis J, Humphries Elizabeth M, Burroughs William, Ament Seth A, Mitchell Braxton D, Ma Tianzhou, Chen Shuo, Medland Sarah E, Blangero John, Hong L Elliot, Kochunov Peter

Abstract excerpt

National and international biobanking efforts led to the collection of large and inclusive imaging genetics datasets that enable examination of the contribution of genetic and environmental factors to human brains in illness and health. High-resolution neuroimaging (~104-6 voxels) and genetic (106-8 single nucleotide polymorphic [SNP] variants) data are available in statistically powerful (N = 103-5)...

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PMID: 39593222
DOI: 10.1002/hbm.70044
PMCID: PMC11599162

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