Article
Massively expedited genome-wide heritability analysis (MEGHA).
Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2015
Ge Tian, Nichols Thomas E, Lee Phil H, Holmes Avram J, Roffman Joshua L, Buckner Randy L, Sabuncu Mert R, Smoller Jordan W
Abstract excerpt
The discovery and prioritization of heritable phenotypes is a computational challenge in a variety of settings, including neuroimaging genetics and analyses of the vast phenotypic repositories in electronic health record systems and population-based biobanks. Classical estimates of heritability require twin or pedigree data, which can be costly and difficult to acquire. Genome-wide complex trait analysis is an...
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