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Human iPSC and CRISPR targeted gene knock-in strategy for studying the somatic TIE2L914F mutation in endothelial cells.

Angiogenesis - 1 Aug 2024

Lazovic Bojana, Nguyen Hoang-Tuan, Ansarizadeh Mohammadhassan, Wigge Leif, Kohl Franziska, Li Songyuan, Carracedo Miguel, Kettunen Jere, Krimpenfort Luc, Elgendy Ramy, Richter Kati, De Silva Laknee, Bilican Bilada, Singh Prateek, Saxena Pratik, Jakobsson Lars, Hong Xuechong, Eklund Lauri, Hicks Ryan

Abstract excerpt

Induced pluripotent stem cell (iPSC) derived endothelial cells (iECs) have emerged as a promising tool for studying vascular biology and providing a platform for modelling various vascular diseases, including those with genetic origins. Currently, primary ECs are the main source for disease modelling in this field. However, they are difficult to edit and have a limited lifespan. To study the effects of targeted...

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Identifiers

PMID: 38771392
DOI: 10.1007/s10456-024-09925-9
PMCID: PMC11303492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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