SERS analysis of cancer cell-derived exosome phenotypes using a rare-earth ion coordination-dominated exosome capture strategy.

Abstract excerpt

Exosomes are important liquid biopsy markers for non-invasive cancer diagnosis, making efficient exosome isolation and precise detection particularly crucial. This study proposes an exosome capture strategy that leverages the coordination effect between rare-earth ions and negatively charged phosphate groups on the exosomal membrane surface, and combines it with surface-enhanced Raman spectroscopy (SERS) to...

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