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An Electrochemical Biosensor Designed by Using Zr-Based Metal-Organic Frameworks for the Detection of Glioblastoma-Derived Exosomes with Practical Application.

Analytical chemistry - 3 Mar 2020

Sun Zhaowei, Wang Lei, Wu Shuai, Pan Yanhong, Dong Yu, Zhu Sha, Yang Jie, Yin Yongmei, Li Genxi

Abstract excerpt

Glioblastoma (GBM) is one of the most fatal tumors in the brain, and its early diagnosis remains technically challenging due to the complex repertoires of oncogenic alterations and blood-brain barrier (BBB). GBM-derived specific exosomes can cross the BBB and circulate in body fluids, so they can be noninvasive biomarkers for the early diagnosis of GBM. Herein, we propose a sensitive and label-free...

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PMID: 32024367
DOI: 10.1021/acs.analchem.9b05241

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