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Article

PWAS Hub: exploring gene-based associations of complex diseases with sex dependency.

Nucleic acids research - 6 Jan 2025

Zucker Roei, Kelman Guy, Linial Michal

Abstract excerpt

The Proteome-Wide Association Study (PWAS) is a protein-based genetic association approach designed to complement traditional variant-based methods like GWAS. PWAS operates in two stages: first, machine learning models predict the impact of genetic variants on protein-coding genes, generating effect scores. These scores are then aggregated into a gene-damaging score for each individual. This score is then used in...

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Identifiers

PMID: 39565197
DOI: 10.1093/nar/gkae1125
PMCID: PMC11701668

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