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A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome

6 Feb 2023

Abstract excerpt

BACKGROUND: DNA methylation of cytosines at cytosine-phosphate-guanine (CpG) dinucleotides (CpGs) is a widespread epigenetic mark, but genome-wide variation has been relatively unexplored due to the limited representation of variable CpGs on commercial high-throughput arrays. OBJECTIVES: To explore this hidden portion of the epigenome, this study combined whole-genome bisulfite sequencing with in silico evidence...

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PMID: 36754293
DOI: 10.1016/j.jaci.2022.12.828

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