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Article

Rapid Pyrazinamide Drug Susceptibility Testing using a Closed-Tube PCR Assay of the Entire pncA gene.

Scientific reports - 6 Mar 2020

Whitfield Michael G, Marras Salvatore A E, Warren Rob M, Van Rie Annelies, Rice John, Wangh Lawrence J, Kreiswirth Barry N

Abstract excerpt

The continued use of pyrazinamide in the treatment of tuberculosis in the absence of a rapid, accurate and standardized pyrazinamide drug susceptibility assays is of great concern. While whole genome sequencing holds promise, it is not yet feasible option in low resource settings as it requires expensive instruments and bioinformatic analysis. We investigated the diagnostic performance of a closed-tube...

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Identifiers

PMID: 32144379
DOI: 10.1038/s41598-020-61286-7
PMCID: PMC7060184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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