Article
Using mutant cycle analysis to elucidate long-range functional coupling in allosteric receptors.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012
Shanata Jai A P, Frazier Shawnalea J, Lester Henry A, Dougherty Dennis A
Abstract excerpt
Functional coupling of residues that are far apart in space is the quintessential property of allosteric receptors. Data from functional studies of allosteric receptors, such as whole-cell dose-response relations, can be used to determine if mutation to a receptor significantly impacts agonist potency. However, the classification of perturbations as primarily impacting binding or allosteric function is more...
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