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Article

Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma

30 May 2019

Abstract excerpt

Poroma is a benign skin tumor exhibiting terminal sweat gland duct differentiation. The present study aimed to explore the potential role of gene fusions in the tumorigenesis of poromas. RNA sequencing and reverse transcription PCR identified highly recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poromas (92/104 lesions, 88.5%) and their rare malignant counterpart, porocarcinomas (7/11 lesions, 63.6%). A...

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PMID: 31145701
DOI: 10.1172/jci126185

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