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Article

Whole-exome sequencing in eccrine porocarcinoma indicates promising therapeutic strategies.

Cancer gene therapy - 1 Jun 2022

Denisova Evgeniya, Westphal Dana, Surowy Harald M, Meier Friedegund, Hutter Barbara, Reifenberger Julia, Rütten Arno, Schulz Alexander, Sergon Mildred, Ziemer Mirjana, Brors Benedikt, Betz Regina C, Redler Silke

Abstract excerpt

Malignant sweat gland tumours are rare, with the most common form being Eccrine porocarcinoma (EP). To investigate the mutational landscape of EP, we performed whole-exome sequencing (WES) on 14 formalin-fixed paraffin-embedded samples of matched primary EP and healthy surrounding tissue. Mutational profiling revealed a high overall median mutation rate. This was attributed to signatures of mutational processes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34045664
DOI: 10.1038/s41417-021-00347-z
PMCID: PMC9209330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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