Article
Identification of mutations in canine oral mucosal melanomas by exome sequencing and comparison with human melanomas.
Scientific reports - 15 Oct 2024
Dagli Maria Lucia Zaidan, Nagamine Márcia Kazumi, Ikeda Tatícia Lieh, da Fonseca Ivone Izabel Mackowiak, Kremer Frederico Schmitt, Seixas Fabiana Kommling, Hernandez Carolina Dagli, Leite João Vitor Pereira, Yasumaru Cassia Correa, Massoco Cristina Oliveira, Hsieh Ricardo, Lourenço Silvia Vanessa, Collares Tiago Veiras
Abstract excerpt
Oral mucosal melanomas (OMMs) are aggressive neoplasms commonly found in dogs but rare in humans. Utilizing whole exome sequencing (WES), which focuses on protein-coding regions to reveal mutation profiles, we conducted a comparative analysis of canine OMM and human melanomas. This study involved DNA extraction, exome enrichment, and sequencing from three canine OMM cell lines (CMGD-2, CMGD-5, TLM-1), five canine...
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