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Article

HOT3/eIF5B1 confers Kozak motif-dependent translational control of photosynthesis-associated nuclear genes for chloroplast biogenesis.

Nature communications - 14 Nov 2024

Hang Runlai, Li Hao, Liu Wenjing, Wang Runyu, Hu Hao, Chen Meng, You Chenjiang, Chen Xuemei

Abstract excerpt

Photosynthesis requires chloroplasts, in which most proteins are nucleus-encoded and produced via cytoplasmic translation. The translation initiation factor eIF5B gates the transition from initiation (I) to elongation (E), and the Kozak motif is associated with translation efficiency, but their relationship is previously unknown. Here, with ribosome profiling, we determined the genome-wide I-E transition...

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PMID: 39543117
DOI: 10.1038/s41467-024-54194-1
PMCID: PMC11564774

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