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Human oncostatin M deficiency underlies an inherited severe bone marrow failure syndrome

23 Jan 2025

Abstract excerpt

Oncostatin M (OSM) is a cytokine with the unique ability to interact with both the OSM receptor (OSMR) and the leukemia inhibitory factor receptor (LIFR). On the other hand, OSMR interacts with IL31RA to form the interleukin-31 receptor. This intricate network of cytokines and receptors makes it difficult to understand the specific function of OSM. While monoallelic loss-of-function (LoF) mutations in OSMR...

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PMID: 39847438
DOI: 10.1172/jci180981

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